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question: is an alkaloid. It's basic. Does anything interesting happens when I add lemon to my ? Does anything interesting happens when I add apple cider to my tea? What if I mixed coffeine with acetic anhydride? It turns morphine into heroine, what does it change coffeine into?

@licho

What if I mixed coffeine with acetic anhydride?

Coffeine cannot be acetylated, therefore there is no effect. No wait, your coffee will be tasting like vinegar.

@organic_chemistry thanks! Why can't it be acetylated? How do we usually know if things can or can't be acetylated?

I'm a dilettante in chemistry, thank you for patience ^^

@licho The molecule of interest need to have a "reactive handle". If you want to add a acetyl, which is called acetylation, you often need something like a free alcohol or amine. E.g. on morphine you have this group (often depicted in the upper left corner, the -OH). Although coffeine has some N atoms, all of them are already occupied and cannot be further substituted under standard conditions.

@organic_chemistry thank you! 🙏 Alkaloid is a misnomer here then, isn't it? Coffeine isn't alkaline after all!

@licho The term alkaloid stands for a class of natural products, which may but not have to be alkaline. However, they always containing nitrogen.